PDI and platelet accumulation in chimeric mice after vascular injury. Chimeric mice were generated by reciprocal bone marrow transplantation between wild-type (WT) and β3^−/− mice. Noninhibitory rabbit anti-PDI antibody (0.5 μg/g body weight) conjugated to Alexa 488 was infused into mice with a nonblocking rat anti–mouse GPIbβ antibody conjugated to DyLight 649 5 minutes before laser-induced arteriolar wall injury. Representative images associated with platelets (red) and PDI (green) are shown over a time course of 180 seconds after vessel injury within the context of the bright-field microvascular histology.