Infarct volumes after transient LAD occlusion in WT mice, Adamts13^−/− mice and WT mice treated with rhADATMS13. Top: Representative TTC stains of transverse sections of the left ventricle (LV) of the 3 groups after 1 hour of LAD occlusion followed by 23 hours of reperfusion. Infarctions appear as white. Bottom: Myocardial infarctions (expressed as percentage of the LV) of the 3 groups as measured by planimetry at day 1 after LAD occlusion (*P < .05 compared with the WT group).