Clonal dynamics in a patient with high-risk MM. The summarized results of 8 different FISH assays are shown to indicate the relative abundance of each clone defined by aCGH at the 5 time points studied. Pie charts showing the relative proportions of each indicated clone are ordered clockwise starting on the left in longitudinal order. Arrow length is proportional to the time interval. The relative ploidy of the tumor population at each time point is also indicated. The cIg FISH of relapse 4 and the PCL identified clonal cells with low levels of cytoplasmic immunoglobulin (cIg-low) and larger cells with abundant cytoplasmic immunoglobulin (cIg-high) that were scored independently.