Coronal sections of the brains of mice treated either with vehicle or PN2KPI. The ischemic region of brain is indicated by the pale area within the right hemisphere of animals treated with vehicle (A) or PN2KPI (B) 24 hours after right middle cerebral artery occlusion. (C-D) The comparison of the stroke volume and stroke fraction between the 2 groups (n = 6 in each group, P < .05). The bars represent the mean ± SEM of stroke volume values. *Significant differences with P < .05 compared with the control group.