Figure 2
Inhibitory effect of PN2KPI on thrombus development in the FeCl3-induced mouse carotid artery thrombosis model. Thrombus formation is recorded by fluorescence microscopy as described in “Carotid artery thrombosis model.” The image of thrombus growth was captured from video clips recorded at different time points. Thrombus growth (A) in a representative untreated mouse and (B) in a PN2KPI-treated mouse was recorded. (C) Thrombus growth, represented by the artificial fluorescence intensity unit (AFU), was measured at various time points (1, 3, 5, 7,10,15, 20, 30, and 40 minutes) in 6 control (□) and 6 PN2KPI-treated (○) mice. Results shown are mean values ± SEM. *Significant differences with P < .05.
