Hemolysis and red blood cell maturation. (A) Levels of hemoglobin (Hb) in WT^BM (open bar) or BERK^BM (filled bar) mice injected with either a rat anti –mouse TF (n = 5 for WT^BM; n = 14 for BERK^BM) or control rat IgG antibodies (n = 8 for WT^BM; n = 14 for BERK^BM). (B) Levels of Hb in TW^AA (open bar) or TW^SS (filled bar) mice injected with either a rat anti–mouse TF (n = 6 for TW^AA; n = 7 for TW^SS) or control rat IgG antibodies (n = 7 for TW^AA; n = 11 for TW^SS). (C-D) Plasma levels of LDH were analyzed in the same group of mice as described for panels A and B. Asterisks directly above the bars indicate statistically significant difference compared with WT^BM or TW^AA controls within the same treatment: *P < .05; **P < .01; and ***P < .001. (E) Representative density plots demonstrating levels of CD71 expression on Ter119⁺ cells (red blood cells) from TW^AA and TW^SS mice treated with 1H1 or IgG. (F) Red blood cell maturation profiles in TW^AA or TW^SS mice treated with 1H1 or IgG (n = 6-11).