American Society of Hematology

Figure 5

Inhibiting Tim-3 in the absence of T-regs reduces gut pathology. (A) B6 mice were lethally irradiated and infused with 107 BALB/c NTCD BM and 3 × 106 BALB/c or Tim-3−/−–purified CD25− T cells. FITC-dextran (16 mg) was administered orally to mice on day 14 (P = .046, n = 4) and days 21(P = .0778, n = 4). Serum levels were measured 4 hours later. (B) B6 mice were lethally irradiated and infused with 107 BALB/c NTCD BM and 3 × 106 BALB/c or Tim-3−/−–purified CD25− T cells. Mice were killed on day 21, and lamina propria lymphocytes were analyzed for effector cytokines.

Inhibiting Tim-3 in the absence of T-regs reduces gut pathology. (A) B6 mice were lethally irradiated and infused with 10⁷ BALB/c NTCD BM and 3 × 10⁶ BALB/c or Tim-3^−/−–purified CD25⁻ T cells. FITC-dextran (16 mg) was administered orally to mice on day 14 (P = .046, n = 4) and days 21(P = .0778, n = 4). Serum levels were measured 4 hours later. (B) B6 mice were lethally irradiated and infused with 10⁷ BALB/c NTCD BM and 3 × 10⁶ BALB/c or Tim-3^−/−–purified CD25⁻ T cells. Mice were killed on day 21, and lamina propria lymphocytes were analyzed for effector cytokines.

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