Figure 4
Inhibiting Tim-3 in the absence of Tregs leads to decreased lethality. (A) B6 mice were lethally irradiated and infused with 107 BALB/c NTCD BM and 3 × 106 BALB/c or Tim-3−/−–purified CD25− T cells. Survival plot of BALB/c (closed circle) versus Tim-3−/− (open circle) donor is shown (P < .001, n = 15/group). (B) B6 mice were lethally irradiated and infused with 107 BALB/c NTCD BM and 106 BALB/c CD4+CD25− T cells. Survival plot of IgG control (closed circle) versus Tim-3-Ig (open circle) treatment is shown (P < .01, n = 8/group).

Inhibiting Tim-3 in the absence of Tregs leads to decreased lethality. (A) B6 mice were lethally irradiated and infused with 107 BALB/c NTCD BM and 3 × 106 BALB/c or Tim-3−/−–purified CD25 T cells. Survival plot of BALB/c (closed circle) versus Tim-3−/− (open circle) donor is shown (P < .001, n = 15/group). (B) B6 mice were lethally irradiated and infused with 107 BALB/c NTCD BM and 106 BALB/c CD4+CD25 T cells. Survival plot of IgG control (closed circle) versus Tim-3-Ig (open circle) treatment is shown (P < .01, n = 8/group).

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