CYT107 induces the expansion of effector memory CD4⁺ and CD8⁺ T cells but no changes in Treg or CD127 expression. (A) CYT107 predominantly induces an expansion of effector memory T cells with an increase in naive CD4⁺ and CD8⁺ T cells in a minority of patients. Each panel represents absolute values of T-cell subsets of CD4⁺ or CD8⁺ T cells using CD45RA and CCR7 expression to distinguish naive (CD45RA⁺CCR7⁺), central memory (CD45RA⁻CCR7⁺), effector memory (CD45RA⁻CCR7⁻), and effector (CD45RA⁺CCR7⁻) T cells. Data for individual patients are shown. (B) CYT107 administration does not affect the relative frequency of Tregs, defined as CD4⁺CD25^hiFoxP3⁺ T cells. Left: Absolute Treg counts for individual patients. Right: Mean ratio Treg count/baseline ± SEM for each cohort. (C) CYT107 administration does not affect long-term expression of CD127 on CD4⁺ or CD8⁺ T cells (data for individual patients shown).