Clinical outcome of children with BCP-ALL enrolled in the BFM ALL 2000 protocol in Austria according to P2RY8-CRLF2. Kaplan-Meier estimates of 5-year pOS (left), pEFS (middle), and CIR (cumulative incidence; right) according to the presence of P2RY8-CRLF2 and its proportion in the leukemia of 248 screened non-DS cases (A,C) and of all 530 non-DS cases (B) enrolled in the treatment study. Analogous analyses of ALL cases treated according to the IR treatment arm (D-F).