DNM3 harbors MEIS1 binding sites and is associated with differences in MPV. (A) Co-occurrence of MPV and PLT count association SNPs with MEIS1 ChIP-seq peaks. (B) Transcript levels of DNM genes during in vitro differentiation of MKs from human cord blood CD34+ cells, as measured by quantitative real-time RT-PCR (n = 3). Error bars represent SD. (C) MPV of the PLTs of persons according to genotype for sentinel SNP rs10914144 (n = 26 of 26). Mann-Whitney test: P = .03.