Figure 5
Figure 5. Effect (mean ± SEM) of iPTH on the SC expression of mRNA of genes known to be up-regulated by Wnt signaling and Jagged1. BM harvested at death was cultured for 1 week. SCs were purified, and mRNA levels determined by real-time RT-PCR. SCs were obtained from WT mice, TCRβKO mice, TCRβKO mice previously subjected to adoptive transfer of WT or Wnt10b−/− T cells, and Wnt10b−/− mice. (A-E) The Wnt-dependent analyzed genes were aryl-hydrocarbon receptor (Ahr), Axin, cystein rich protein 61 (Cyr61), naked cuticle 2 homolog (Nkd2), transgelin (TagIn), transforming growth factor β 3 (TGFβ3), thrombospondin 1 (Thbs1), Twist gene homolog 1 (Twst1), and Wnt1 inducible signaling pathway protein 1 (Wisp1) and Jagged1. n = 5 mice per group. *P < .05 versus the corresponding vehicle-treated group.

Effect (mean ± SEM) of iPTH on the SC expression of mRNA of genes known to be up-regulated by Wnt signaling and Jagged1. BM harvested at death was cultured for 1 week. SCs were purified, and mRNA levels determined by real-time RT-PCR. SCs were obtained from WT mice, TCRβKO mice, TCRβKO mice previously subjected to adoptive transfer of WT or Wnt10b−/− T cells, and Wnt10b−/− mice. (A-E) The Wnt-dependent analyzed genes were aryl-hydrocarbon receptor (Ahr), Axin, cystein rich protein 61 (Cyr61), naked cuticle 2 homolog (Nkd2), transgelin (TagIn), transforming growth factor β 3 (TGFβ3), thrombospondin 1 (Thbs1), Twist gene homolog 1 (Twst1), and Wnt1 inducible signaling pathway protein 1 (Wisp1) and Jagged1. n = 5 mice per group. *P < .05 versus the corresponding vehicle-treated group.

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal