VWF domain annotations. Cysteines are shown as vertical lines and are connected for chemically defined disulfide bonds.^13,14  N- and O-linked glycans are shown as closed and open lollipops, respectively.¹²  (A) Commonly used domain assignment in the literature.²  (B) Annotation in protein databases according to regions of sequence homology. (C) Domain architecture assigned in the present study. Additional disulfide bonds are from predictions described in the text. Boundaries of D assemblies are shown as vertical dashed lines. (D) Dimeric bouquets in acidic pH as found in the Golgi. Organization of the A1-CTCK region is from Zhou et al.¹⁷  Organization of the D1-A1 region is predicted based on data of Huang et al.¹⁶