Evolution patterns in patients with differing levels of evolution. Samples from 2 representative patients with no evolution (patient 36) and high evolution (patient 50) are shown. J_H and V_H segments are shown on the x-axis, with clone frequency in logarithmic scale on the y-axis. A single higher-frequency clonotype is seen in the sample with no evolution (patient 36). Two higher-frequency clonotypes that share 1 J_H segment but have different V_H segments are observed in the patient with a high degree of evolution (patient 50).