Peripheral deletion mediated by PD-L1 expression on lymphatic endothelial cells (LECs) in lymph nodes. (A) Location of LECs within the lymph node. (B) Interaction of PD-1 on CD8 T cells and PD-L1 on LECs mediates deletion. LECs express Class II MHC and HVEM, but those molecules do not appear to play a role in the peripheral deletion of tyrosinase-specific CD8 T cells. Modified from Turley et al.⁶