Targeted resequencing results of 50 paired tumor-remission AML samples. (A) Distribution of numbers and categories of somatically acquired point mutations among the 50 cases. (B) Fraction of reads reporting mutated frameshift/missense/nonsense alleles from targeted resequencing data for each case. No frameshift/missense/nonsense mutations were found for cases 26 and 40. Mutations in recurrently mutated AML genes identified in this screen are shown as colored points, with nonrecurrent mutations as black points. CBF-AML indicates core-binding factor AML; CK-AML, complex karyotype AML; CN-AML, cytogenetically normal AML; FLT3*, FLT3 with internal tandem duplications (FLT3-ITD); dbSNP132, single nucleotide polymorphism database, build 132, NCBI; UTR, untranslated region; and ncRNA, noncoding RNA.