Overview of the data-filtering procedure for the identification of single nucleotide variations (SNVs) in paired tumor-remission AML samples (n = 50). (A) Overview and numbers of SNVs in the individual filtering steps. A detailed description of the filtering parameters is given in supplemental Methods. All detected SNVs and indels are listed in supplemental Table 4. (B) Mean number of SNVs per patient with certain properties. dbSNP132 indicates single nucleotide polymorphism database, build 132, NCBI; UTR, untranslated region; and ncRNA, noncoding RNA.