Small-molecule drug targeting NIK protein specifically reduces HL cell line viability. (A-C) Treatment of L1236, KM-H2, and U-H01 HL cell lines with the NIK inhibitor 4H-isoquinoline-1,3-dione. (D-E) Med-B1 and K1106 cell line survival is not affected by 4H-isoquinoline-1,3-dione. (F-H) Neither HBL-1 (F) nor HT (G) nor BJAB (H) cell lines were sensitive to the 4H-isoquinoline-1,3-dione. Error bars represent the SD of quadruplicates from a representative experiment.