Characterization of transplanted Vk*MYC mice. (A) Peripheral blood hemoglobin and (B) plasma creatinine levels from tVk*MYC mice compared with nontumor-bearing controls. (C) Renal cast nephropathy, typical of autopsy findings from terminal mice bearing aggressive tVk*MYC MM. (D) Transmission electron microscopy of the glomerular basement membrane (GBM) from a normal C57BL/6 mouse compared at the same magnification to GBM from a tumor-bearing mouse. Note diffuse GBM thickening indicating glomerulopathy. (E) Tibial trabecular bone volume of tVk*MYC myeloma-bearing mice (n = 3) compared with irradiated, age-matched wt controls (n = 3). (F) Histologic evidence of bone lysis in the femoral shaft of a tVk*MYC mouse. (G) Representative micro-CT scans demonstrating cortical lytic lesions in the tibial plateau and fibula from mice bearing the same clone.