Simplified scheme of BCR-triggered glucosylation of ceramides. (A) BCR engagement results in up-regulation of UGCG expression and glucosylation of ceramides with a concomitant ABT-737 resistance. (B) Direct inhibition of UGCG or repression of UGCG expression via CAL-101 or PCI-32765 after BCR stimulation results in synergistic apoptosis during ABT-737 treatment.