Molecular responses of CML-CP patients, by treatment arm and time on study. Changes of BCR-ABL mRNA level, relative to group-specific median baseline values, are shown on a common log (log₁₀) scale for patients randomized to DAS (+) or IM (○) therapy. Values reported as “non-detect” are assigned 6-log reduction. Curved lines are fitted models for mean change from baseline for DAS (solid) or IM (dashed). Horizontal dashed lines indicate no change, 3-log and 4-log reduction from baseline.