Figure 6
CRT is not involved in the engulfment of HSCs in HLH. (A) CRT expression in normal hematopoietic cells. CRT expression index represents the relative surface CRT level calculated as median CRT levels of analyzed cells/those in normal blood mononuclear cells. Error bars show 1 SD differences. (B) CRT expression in CD34+CD38− HSCs, CD34+CD38+ progenitors, and unfractionated BM cells from HLH patients and healthy controls. The expression level of CRT was equivalent in HLH patients and healthy controls in all of these cell fractions. **P < .05 by conventional t test. (C) The effect of cytokines on CRT expression. CRT expression was not changed irrespective of incubation with cytokines in any of these cell fractions. Bars show the mean values.

CRT is not involved in the engulfment of HSCs in HLH. (A) CRT expression in normal hematopoietic cells. CRT expression index represents the relative surface CRT level calculated as median CRT levels of analyzed cells/those in normal blood mononuclear cells. Error bars show 1 SD differences. (B) CRT expression in CD34+CD38 HSCs, CD34+CD38+ progenitors, and unfractionated BM cells from HLH patients and healthy controls. The expression level of CRT was equivalent in HLH patients and healthy controls in all of these cell fractions. **P < .05 by conventional t test. (C) The effect of cytokines on CRT expression. CRT expression was not changed irrespective of incubation with cytokines in any of these cell fractions. Bars show the mean values.

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