EC-SP degrades Bcl-xL protein in platelets. (A) Western blot analysis of Bcl-xL protein expression in platelets incubated with EC-SP (4 or 8 hours). (B) Western blot analysis of platelets stimulated with vehicle (control), thrombin (Thr), PAF, or A23187 (1μM) for 8 hours. The Western blots in panels A and B are representative of 2-4 independent experiments for each experimental group.