Antigen-specific antibody titers at baseline and after CTL019 infusion. (A) S pneumoniae–, (B) H influenzae type B–, (C) tetanus toxoid–, (D) measles-, (E) mumps-, and (F) rubella-specific IgG, and (G) HSV1/2-specific IgA levels were measured in CTL019-treated patients who experienced persistent B-cell aplasia. For anti-H influenzae, -tetanus toxoid, -rubella, and anti-measles, thresholds of protective IgG levels are indicated by the dashed lines. For anti-S pneumoniae, anti-mumps, and anti-HSV1/2 IgA, the dashed lines indicate the lower limit of detection. Error bars indicate standard deviations.