Representative images of thrombus formation in arterioles from huVWFmuA1-expressing mice treated with mAbs to VWF. Four- to 5-week-old VWF^−/− mice expressing huVWFmuA1 were treated with 100 μg/mouse of mAb 9 (recognizing RGD-motif), mAb 203 or mAb 505 (both recognizing A3 domain) 4 days after hydrodynamic injection. Platelets were labeled in vivo through injection of rhodamine 6G before mesentery dissection. Vessel injury was induced by exposure of arterioles to 7.5% FeCl₃. The experiment was recorded until occlusion or until 40 minutes in absence of occlusion. Pictures were taken at different time points after induction of vessel wall injury. White arrows point to embolization.