TP53 mutations: localization and association with cytogenetics and other molecular mutations. (A) Molecular mutations in TP53. The numbers of mutations are reflected by the numbers of colored dots which also indicate the mutation effect on the amino acid level. (B) Association between TP53 mutations and karyotype. The Circos plot illustrates the association between TP53 mutations and cytogenetic subgroups. The width of the arches indicates the percentage of positive samples. (C) Mutational complexity of TP53 mutations. The Circos diagram shows the mutational events in patients with TP53 mutations and a respective second molecular mutation. The length of the gene section indicates the number of obtained mutations per marker. The width of the arches indicates the percentage of mutated samples.