Inhibition of ADAMTS13 parameters by 3H9. (A) ADAMTS13:Activity (%) and (B) ADAMTS13:Antigen (μg/mL) were measured in plasma of the control (●; n = 4), preventive (□; n = 4), and therapeutic (; n = 4) animals as a function of time (days). The lower limit of quantification of the ADAMTS13:Activity assay was determined to be 4.4% and is indicated by the dashed line. Results were analyzed with a mixed model and a posthoc test with Tukey multiple comparison adjustment. Data are represented as means ± SD. “a” indicates a significant difference between control and preventive animals (P < .05).