Impaired pneumococcal clearance and increased pneumococcal dissemination in CD11c.Cre^pos -LPL^fl/fl and CD11c.Cre^pos -LPL^fl/+ mice. (A) Mice of indicated genotypes were challenged via intratracheal injection of 5 × 10⁴ colony-forming units (cfu) of S pneumoniae serotype 3. After 24 hours, bacterial colony-forming units in harvested BAL fluid were determined by serial dilution. Number of mice shown along the x-axis; data combined from at least 3 independent experiments. (B) Percentage of mice with positive blood cultures following pulmonary pneumococcal infection.