Kinetics of miR-378-3p induction during in vitro alternative activation. Thio-elicited, adherence-purified MΦ were incubated with rIL-4 (black squares), LPS and rIFNγ (gray triangles), or with medium alone (open squares) for the indicated time and analyzed for miRNA and mRNA expression. Statistics indicate differences between rIL-4–treated samples and media controls. **P < .01; ***P < .001. Each data point represents mean and SEM of 3 individual animals. One of 2 separate experiments shown.