Figure 4
Figure 4. IFNγ directs myelopoiesis during LCMV infection. (A) Number of GMPs in BM of WT and IFNγ−/− naive mice and 8 days after LCMV infection. (B) Representative plot of BrdU staining in monocytes in the peripheral blood of naive and LCMV-infected mice 8 days after infection and absolute numbers of BrdU+ monocytes in peripheral blood (C) and BM (D) of these mice. (E) Number of BrdU+ neutrophils in the peripheral blood of naive and LCMV-infected mice 8 days after infection. (F-G) Representative plot of BrdU staining in neutrophils in BM (F) and number of BrdU+ neutrophils in BM of these mice (G) are shown. Data in panels A, C, D, and E represent means ± SD from 5 mice per group; BM represents cell numbers per 2 femurs and 2 tibiae. Experiments were performed at least 2 times with similar results. *P < .05; **P < .01; ***P < .001.

IFNγ directs myelopoiesis during LCMV infection. (A) Number of GMPs in BM of WT and IFNγ−/− naive mice and 8 days after LCMV infection. (B) Representative plot of BrdU staining in monocytes in the peripheral blood of naive and LCMV-infected mice 8 days after infection and absolute numbers of BrdU+ monocytes in peripheral blood (C) and BM (D) of these mice. (E) Number of BrdU+ neutrophils in the peripheral blood of naive and LCMV-infected mice 8 days after infection. (F-G) Representative plot of BrdU staining in neutrophils in BM (F) and number of BrdU+ neutrophils in BM of these mice (G) are shown. Data in panels A, C, D, and E represent means ± SD from 5 mice per group; BM represents cell numbers per 2 femurs and 2 tibiae. Experiments were performed at least 2 times with similar results. *P < .05; **P < .01; ***P < .001.

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