RanBP10^−/− mice show impaired thrombus formation in an arterial thrombosis model. (A) The onset of thrombus formation after FeCl₃-induced injury is unaffected (top panel). In wild-type mice vessels are occluded within 20 minutes whereas in mutant animals no stable clot is formed within 40 minutes observation time (bottom panel). (B) Quantification reveals that in wild-type mice 8 of 9 injured arterioles show normal occlusion, although this was only present in 5 of 13 arterioles of RanBP10^−/− mice. In 8 of 13 arterioles we found no occlusion or recanalization within the observation time.