TP63 rearrangements in DLBCLs. (A) DLBCL with TP63 rearrangement (hematoxylin and eosin, 400×). (B) Immunohistochemistry for the B-cell antigen, CD20 (400×). (C) Tumor cells showed strong nuclear expression of p63 protein (400×; inset, isotype control). (D) Dual-fusion FISH showed 2 fusion signals (arrows), corresponding to TBL1XR1/TP63 fusion. (E) TP63 rearrangements were seen in 1.2% of DLBCLs by FISH. The SnowShoes fusion detection algorithm did not identify TP63 fusions in transcriptome data from carcinomas (ca) of the breast, lung, or head and neck (H&N), nor in data from normal controls.