Use of expression levels of genes versus subnetworks to stratify patient samples. (A) Five-fold cross-validation on the 130 patients evaluated at UC San Diego. Survival analyses on SC→TX are shown for both the low- (dashed lines) and high- (solid lines) risk groups predicted by subnetwork signatures (black lines) or by gene signatures (gray lines). (B-C) Survival curves on SC→TX for (B) the 17 European patients or for (C) the patient cohort in Friedman et al.²⁶  The 2 risk groups are predicted by 2 sets of markers developed on the UC San Diego cohort, including the 38 subnetworks (black lines) and the top 230 genes (gray lines).