Example subnetworks of CLL disease progression enriched for the hallmarks of cancer. (A-O) Pro-onconets. (P-T) Anti-onconets. Nodes and links represent human proteins and protein physical interactions, respectively. Blue links indicate protein-protein interactions; black arrows indicate protein-DNA binding. The color of each node scales with the change in gene expression in patients of shorter treatment-free survival intervals versus longer: red represents up-regulation in patients of shorter intervals whereas green represents down-regulation. The predominant cellular functions are indicated next to each subnetwork. Known cancer susceptibility genes are highlighted by a black asterisk. Names of genes marked in red/green are further probed for serial expression in an additional patient cohort (red indicates genes expressed in pro-onconets and green indicates those expressed in anti-onconets).