Integrative analysis of copy number and gene expression in microdissected HRS cells (n = 29). Genome-wide copy number data are represented by chromosomal position (x-axis) and the relative frequency of imbalances as shown on the y-axis. Red represents gains; and blue, deletions. A selection of genes in regions of frequent imbalances and with significant correlations between copy number and gene expression are highlighted in the vertical yellow bar plot (the full list of genes is provided in supplemental Table 4). The horizontal red dotted line indicates the P value threshold of significance. Target genes are also highlighted on the copy number plot by arrows (cytoband). High resolution views (boxes) of chromosome 9p and 17q are provided to assist in visualizing multiple adjacent genes.