Figure 2.
Figure 2. TMA is associated with all type I IFN subtypes in clinical use. (A) An overview of type I IFN signaling. IFN-α and IFN-β act via the transmembrane IFNAR, leading to widespread upregulation of IRGs (three-dimensional protein models rendered using PyMOL Molecular Graphics System, version 1.8.2.2, Schrödinger LLC, with protein data obtained from the Protein Data Bank,43 http://www.rcsb.org). (B) Dendrogram of human recombinant IFN subtypes in clinical use. Recombinant type I IFN proteins associated with TMA highlighted in red (see supplemental Figure 1 for full details). (C) Comparison of the transcriptomic response of HUVECs to human IFN-α and IFN-β.14 The transcriptional response of HUVECs to both type I IFN subtypes is highly correlated (r = 0.97; genes with fold-change >1 shown).

TMA is associated with all type I IFN subtypes in clinical use. (A) An overview of type I IFN signaling. IFN-α and IFN-β act via the transmembrane IFNAR, leading to widespread upregulation of IRGs (three-dimensional protein models rendered using PyMOL Molecular Graphics System, version 1.8.2.2, Schrödinger LLC, with protein data obtained from the Protein Data Bank,43 http://www.rcsb.org). (B) Dendrogram of human recombinant IFN subtypes in clinical use. Recombinant type I IFN proteins associated with TMA highlighted in red (see supplemental Figure 1 for full details). (C) Comparison of the transcriptomic response of HUVECs to human IFN-α and IFN-β.14  The transcriptional response of HUVECs to both type I IFN subtypes is highly correlated (r = 0.97; genes with fold-change >1 shown).

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