Vasostatin levels inversely correlate with MVD in patients with AML. Immunohistochemical staining of bone marrow biopsies with von VWF identifying endothelial vessel structures (stained brown). Panels A and B represent 2 patients with high vasostatin levels and low MVD, whereas panels C and D depict 2 patients with low CRT serum levels and high MVD. Inlays reveal greater magnification of the individual overview images. Panel E depicts the number of microvessels (enumerated in the VWF staining) per 10 HPF in the individual bone marrow biopsies (P = .0495; mean ± SD; high vasostatin levels: 44 ± 25/10 HPF vs low vasostatin levels: 59 ± 24/10 HPF).