The relative levels of miR-125b target transcripts encoding key enzymes or regulators of metabolism increase in patients with CLL. The relative levels of the coding sequences (CDS) of the indicated transcripts were determines by qRT-PCR in IND and AGG CLL patients as well as in HD. P values (Student t test) are given for Indolent (n = 20) and AGG (n = 20) versus HD (n = 10), or for AGG versus IND (above the bars). Boxes include values from the first to the third quartiles; o indicates extreme data points; +, median; and x, mean ± SD.