iNKT cell reconstitution after allogeneic transplantation. (A) iNKT cells are double stained by anti-CD3 and the PBS57-loaded CD1d-tetramer. Empty CD1d-tetramer was used as a negative control. (B) Evolution of the iNKT/T ratios between day 15 and 90 after HSCT (each line represents 1 patient) in the 71 analyzed patients (data were available for 56/71 patients on day 15, 67/71 on day 30, 66/71 on day 60, and 60/71 on day 90). Two patterns of reconstitution are observed: patients reaching a physiologic iNKT/T ratio ≥ 10−3 during the period of analysis and those with all iNKT/T ratios < 10−3. (C) Means of longitudinally measured iNKT/T ratios from days 15-90 of the 71 analyzed patients regarding whether they had reached the threshold of 10−3 during that period of time. Patients reaching the threshold at least once have also a mean of iNKT/T ratio > 10−3.
