Weak linkage between the HLA-DP loci and the class I and telomeric portion of the class II regions of the MHC is primarily attributable to hot spots of recombination that lie just telomeric of HLA-DP. Map of observed recombination rate within an 8-Mb interval of chromosome 6p that spans the classic MHC. Adapted from de Bakker et al with permission.¹¹⁰