Gene structure and protein organization of Egfl7. (A) The Egfl7 gene consists of 11 exons and a miRNA, miR126, embedded in the intronic region located downstream of exon 7. The protein is encoded in exons 3-10 (red boxes). (B) The EGFL7 protein sequence contains several putative protein domains, including a signal peptide (blue box), an EMI domain (yellow box), an EGF domain that contains a Delta-Serrate-LAG-2 (DSL) motif (orange box), and a Ca2⁺ binding EGF domain (red box).