Effects of coadministration of HU and BAY73-6691 on leukocyte recruitment in TNF-α–treated native SCD mice. HU (100 mg/Kg, intravenously) and BAY73-6691 (3 mg/Kg, intravenously) were administered to native SCD mice at the time of TNF-α administration. (A) leukocyte rolling; (B) adhesion; and (C) extravasation were determined at 180 minutes after TNF-α (**P < .01, ***P < .001 compared with vehicle control, n = 3 mice per group).