Genome-wide transcriptome analysis of JQ1-treated cells. (A) Volcano plots of gene expression differences for MHH-CALL4 and MUTZ-5 cells treated with vehicle or 500nM JQ1 for 8 hours. (B) Correlation of gene expression changes between MHH-CALL4 and MUTZ-5 cells treated with JQ1. (C) Heatmap of the top 50 significantly up- and down-regulated genes. P < .01. Each gene row is normalized to mean expression level (M4 = MHH-CALL4; M5 = MUTZ-5). (D) RMA-normalized expression values for all expressed cytokine receptors. (E) Gene set enrichment analysis of 2 c-Myc signatures. (F) c-Myc and NF-κB binding site gene sets. (G) STAT5A binding site gene set. (H) An antiapoptosis gene set. NES indicates normalized enrichment score; and q = false discovery rate.²⁷