Time to success by treatment arm. (A) Kaplan-Meier plot showing the time to tolerance for the 66 patients who achieved a success, partial success, or failure end point, broken down by HD and LD treatment arm. (B) Intention-to treat Kaplan-Meier plot showing the time to tolerance for all 115 patients randomized and broken down by treatment arm. This plot shows no significant difference between treatment arms (P = .942), but a lower success rate because those not completing ITI or who were withdrawn for logistical reasons are also included.