Figure 3
Figure 3. Induction of mir-15a and miR-16 in 13q+ and 13q− CLL on HDAC inhibition. (A) Increase in miR-15a expression in 13q+ and 13q− CLL samples after exposure to 10nM LBH589 for 3-6 hours. The -fold increase after exposure to LBH589 was calculated and then represented as the increase in expression over levels of expression (as determined in Figure 1B) in untreated cells. The arrow (←) marks samples with del13q as the sole abnormality that induced miR-15a. (B) Increase in miR-16 in 13q+ and 13q− CLL samples after exposure to 10nM LBH589. The -fold increase after exposure to LBH589 was calculated and is represented as the change in expression over levels of expression (as determined in Figure 1C) in untreated cells. The arrows (←) mark samples with del13q as the sole abnormality that induced miR-16 (C) Induction of miR-15a and miR-16 in a CLL sample after exposure to the HDAC inhibitors SAHA (3μM) and MS275 (3μM) for 3-6 hours.

Induction of mir-15a and miR-16 in 13q+and 13q−CLL on HDAC inhibition. (A) Increase in miR-15a expression in 13q+ and 13q− CLL samples after exposure to 10nM LBH589 for 3-6 hours. The -fold increase after exposure to LBH589 was calculated and then represented as the increase in expression over levels of expression (as determined in Figure 1B) in untreated cells. The arrow (←) marks samples with del13q as the sole abnormality that induced miR-15a. (B) Increase in miR-16 in 13q+ and 13q− CLL samples after exposure to 10nM LBH589. The -fold increase after exposure to LBH589 was calculated and is represented as the change in expression over levels of expression (as determined in Figure 1C) in untreated cells. The arrows (←) mark samples with del13q as the sole abnormality that induced miR-16 (C) Induction of miR-15a and miR-16 in a CLL sample after exposure to the HDAC inhibitors SAHA (3μM) and MS275 (3μM) for 3-6 hours.

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