Figure 6
Figure 6. Cytokine-producing (virus-specific) CD8+ T cells in the PB and LNs. (A) Percentages of IL-2–, TNFα-, IFNγ-, and MIP-1β–producing, CD107a-expressing, and polyfunctional (PF) cells of CMV-specific CD8+ T cells after stimulation with various concentrations of cognate peptide for 6 hours in the presence of brefeldin A and GolgiStop. The filled circles (●) with the bold line represent the means ± SEM of PB of 4 patients. The open circles (○) with the dotted line represent the means ± SEM of LN cells of the same 4 patients. *P < .05. (B-D) Percentage of IL-2-producing (B), IFNγ-producing (C), and PF cells (D) within, from left to right; total, CMV-, EBV-, and FLU-specific CD8+ T cells after stimulation with PMA and ionomycin for 4 hours in the presence of brefeldin A and GolgiStop. Paired samples were analyzed using the Wilcoxon signed-rank test.

Cytokine-producing (virus-specific) CD8+ T cells in the PB and LNs. (A) Percentages of IL-2–, TNFα-, IFNγ-, and MIP-1β–producing, CD107a-expressing, and polyfunctional (PF) cells of CMV-specific CD8+ T cells after stimulation with various concentrations of cognate peptide for 6 hours in the presence of brefeldin A and GolgiStop. The filled circles (●) with the bold line represent the means ± SEM of PB of 4 patients. The open circles (○) with the dotted line represent the means ± SEM of LN cells of the same 4 patients. *P < .05. (B-D) Percentage of IL-2-producing (B), IFNγ-producing (C), and PF cells (D) within, from left to right; total, CMV-, EBV-, and FLU-specific CD8+ T cells after stimulation with PMA and ionomycin for 4 hours in the presence of brefeldin A and GolgiStop. Paired samples were analyzed using the Wilcoxon signed-rank test.

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal