Figure 1
Hematologic changes after infusions of 211At–anti-CD45 mAb without bone marrow transplantation. Granulocyte, lymphocyte, and platelet counts in 6 dogs treated with 100 to 618 μCi/kg 211At-labeled anti-CD45 on day 0. The total anti-CD45 dose was 0.5 mg/kg, whereof 10% was administered as unlabeled mAb 1 hour before the radioimmunoconjugate. The solid and dashed curves represent median values from historical controls treated with 200 cGy (n = 13)30 or 213Bi-anti-CD45 (n = 4)10 without HCT rescue, respectively.
