Overview of in vivo systems for generating transgenic platelets. Experimental design to generate transgenic zebrafish embryos using MO technology (left), platelet-specific KO mice with the Cre-LoxP method (middle), or genetically modified human or murine platelets by transduction of hematopoietic progenitor cells followed by transplantation in myelo-conditioned recipient mice (right). (Figure was produced using Servier Medical Art; http://www.servier.com/servier-medical-art.) MK/Plt indicates megakaryocyte or platelet-specific promoter.