Hematopoetic and platelet-specific deficiency of Syk and Clec1b result in defective lymphatic development. The phenotypes of (A) Syk^fl/flVav-iCre, (B) Syk^fl/flPF4-Cre, and (C) Clec1b^fl/flPF4-Cre embryos at E14.5 are indistinguishable and include edematous swelling (asterisk), hemorrhages (blue arrow) and blood-filled lymphatics in the skin (black arrowhead). This phenotype is not seen in control littermates. The figures shown are representative of > 5 embryos of each genotype.