Treatment of pPCL. Flow chart with suggestions for how to treat patients with pPCL. *Consolidation for non–transplant-eligible patients is given once best response to induction therapy is achieved. Varicella zoster virus prophylaxis with acyclovir or valacyclovir is recommended for all patients receiving bortezomib-based therapy. Thromboprophylaxis (aspirin for patients at standard risk for thromboembolic events and low-molecular-weight heparin or adjusted-dose warfarin in high-risk patients) is indicated when either thalidomide or lenalidomide is combined with dexamethasone or chemotherapy. MUD indicates matched unrelated donor; DLI, donor lymphocyte infusion; PAD, bortezomib, adriamycin, and dexamethasone; CVD, cyclophosphamide, bortezomib, and dexamethasone; VMP, bortezomib, melphalan, and prednisone; and RIC, reduced intensity conditioning.